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Bioorg Med Chem Lett. 2011 May 15;21(10):3066-9. doi: 10.1016/j.bmcl.2011.03.041. Epub 2011 Mar 17.

Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors.

Author information

1
School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.

Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces cancer cell apoptosis while sparing non-transformed lung fibroblast.

PMID:
21463944
DOI:
10.1016/j.bmcl.2011.03.041
[Indexed for MEDLINE]

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