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N Engl J Med. 2011 Apr 28;364(17):1617-25. doi: 10.1056/NEJMoa1100358. Epub 2011 Apr 4.

Myocardial viability and survival in ischemic left ventricular dysfunction.

Collaborators (416)

Cherniavsky A, Marchenko A, Romanov A, Wos S, Deja M, Golba K, Malinowski M, Gradinac S, Kosevic D, Vukovic M, Djokovic L, Krzeminska-Pakula M, Jaszewski R, Drozdz J, Chrzanowski L, Rajda M, Ali I, Howlett J, MacFarlane M, Jain A, Shah H, Rakshak D, Saxena A, Zembala M, Przybylski R, Kukulski T, Wasilewski J, Wiechowski S, Brykczynski M, Kurowski M, Mokrzycki K, Sadowski J, Kapelak B, Sobczyk D, Plicner C, Wrobel K, Piegas L, Paulista P, Farsky P, Veiga Kantorowitz C, Sadowski Z, Juraszynski Z, Szwed H, Dabrowski R, Rogowski J, Pawlaczyk R, Rynkiewicz A, Betlejewski P, Siepe M, Geibel-Zehender A, Cuerten C, Higgins R, Crestanello J, Binkley P, Jones D, Sun B, Velazquez E, Smith P, Milano C, Adams P, Hill J, Beaver T, Leach D, Airan B, Das S, Yii M, Prior D, Mack J, Rao V, Iwanochko R, Renton J, Panchavinnin P, Phuangkaew N, Bochenek A, Krejca M, Trusz-Gluza M, Wita K, Ferrazzi P, Gavazzi A, Senni M, Natarajan S, Padmanabhan C, Racine N, Bouchard D, Ducharme A, Brown H, Alotti N, Lupkovics G, Kumar S, Agarwal S, Sinha N, Rai H, Andersson B, Janssen A, Lamy A, Demers C, Rizzo T, Doenst T, Garbade J, Thiele H, Richter M, Petrie M, Murday A, Shaw M, Raju K, Mannam G, Reddy G, Rao K, Nicolau J, Stolf N, Vieira A, Chua YL, Lim CH, Kwok B, Gan YC, Cleland J, Cale A, Thackray S, Lammiman M, Michler R, Swayze R, Maurer G, Grimm M, Lang I, Adlbrecht C, Daly R, Rodeheffer R, Nelson S, Larbalestier R, Wang X, Haddad H, Hendry P, Donaldson J, Menicanti L, Di Donato M, Castelvecchio S, Sirvydis V, Voluckiene E, Di Benedetto G, Attisano T, Favaloro R, Favaloro L, Diez M, Riccitelli M, Picone V, Koslowski P, Gaito M, Al-mohammad A, Braidley P, Steele H, Nawarawong W, Woragidpoonpol S, Kuanprasert S, Mekara W, Kon N, Hammon J, Wells G, Tilley W, Drazner M, DiMaio M, Peschka S, De Pasquale C, Knight J, Aylward P, Thomas C, Gullestad L, Sorensen G, Kaul U, Gupta R, Schmedtje J Jr, Arnold S, Wilson V, Grayburn P, Hamman B, Hebeler R, Aston S, Birjiniuk V, Harrington M, Dupree C, Sheridan B, Schuler C, Helou J, Denis I, Bigalli D, Gutierrez F, Russo N, Batlle C, White H, Alison P, Stewart R, Borthwick L, Philippides G, Shemin R, Fitzgerald C, Dagenais F, Dussault G, Kamath P, Busmann C, Ferrari G, Botto M, Horkay F, Hartyanszky I, Bartha E, Simor T, Papp L, Toth L, Varga-Szemes A, Horkay F, Szekely L, Keltai M, Edes I, Szathmarine V, Yakub M, Sarip S, Maitland A, Isaac D, Holland M, Bogats G, Csepregi L, Maia L, Soares M, Mouco O, Souza A, da Rocha AC, Brito JR, Pitella FM, Camara AG, Horowitz J, Knight J, Rose J, McRae R Jr, Geiss D, Clemson B, Pierson M, Kron I, Kern J, Bergin J, Phillips J, Rich J, Herre J, Pine L, Chin D, Spyt T, Logtens E, Amuchastegui L, Bracco D, Ruengsakulrach P, Pitiguagool V, Sukhum P, Srinualta D, Hayward C, Herrera C, Zimmermann R, Patterson G, Stephens W, Dignan R, French J, Sequalino N, Vaishnav S, Panda R, Chavan A, Benetis R, Jankauskiene L, Kalil R, Nesralla I, Santos M, de Moraes M, Friedrich I, Buerke M, Paraforos A, Konda S, Leone C, Murphy E, Ravichandran P, Avalos K, Hetzer R, Knosalla C, Hoffmann K, Landolfo K, Landolfo C, Park M, Chiariello L, Nardi P, Stapleton D, Hoey K, Hasaniya N, Wang N, Bijou R, Naka Y, Ascheim D, Mikati I, Arnold M, McKenzie N, Smith J, Gheorghiade M, Fullerton D, Roberts L, Carson P, Dupree C, Miller A, Pina I, Selzman C, Wertheimer J, Goldstein S, Cohn F, Hlatky M, Kennedy K, Rankin S, Robbins R, Zaret B, Rouleau J, Barfield T, Desvigne-Nickens P, Jones R, Lee K, Michler R, O'Connor C, Oh J, Rankin G, Sopko G, Velazquez E, Hill J, Bonow R, Desvigne-Nickens P, Doenst T, Jones R, Lee K, Michler R, Oh J, Panza J, Rouleau J, Sadowski Z, Sopko G, Velazquez E, White H, Pohost G, Agarwal S, Apte P, Doyle M, Forder J, Ocon M, Pai R, Reddy V, Santos N, Tripathi R, Varadarajan P, Oh J, Pellikka P, Miller F Jr, Lin G, Borgeson D, Ommen S, Casaclang-Verzosa G, Miller D, Springer R, Blahnik F, Manahan B, Welper J, Wiste H, Mark D, Anstrom K, Baloch K, Burnette A, Cowper P, Davidson-Ray N, Drew L, Harding T, Hunt V, Knight D, Patterson A, Redick T, Sanderford B, Feldman A, Bristow M, Chan T, Maisel A, Mann D, McNamara D, Bonow R, Holly T, Berman D, Leonard S, Helmer D, Woods M, Panza J, McNulty M, Asch F, Rumsey M, Bieganski S, Grayburn P, Aston S, Roberts B, Handschumacher M, Jones R, Velazquez E, O'Connor C, Rankin G, Barfield T, McCormick A, Albright J, Dandridge R, Rittenhouse L, Wagstaff D, Williams M, Bailey D, Glover D, Parrish L, Wakeley N, Jackson V, Nicholson B, Lee K, She L, McDaniel A, Al-Khalidi H, Greene D, Moore V.

Author information

1
Center for Cardiovascular Innovation, Northwestern University Feinberg School of Medicine, 645 N. Michigan Ave., Suite 1006, Chicago, IL 60611, USA. r-bonow@northwestern.edu

Abstract

BACKGROUND:

The assessment of myocardial viability has been used to identify patients with coronary artery disease and left ventricular dysfunction in whom coronary-artery bypass grafting (CABG) will provide a survival benefit. However, the efficacy of this approach is uncertain.

METHODS:

In a substudy of patients with coronary artery disease and left ventricular dysfunction who were enrolled in a randomized trial of medical therapy with or without CABG, we used single-photon-emission computed tomography (SPECT), dobutamine echocardiography, or both to assess myocardial viability on the basis of prespecified thresholds.

RESULTS:

Among the 1212 patients enrolled in the randomized trial, 601 underwent assessment of myocardial viability. Of these patients, we randomly assigned 298 to receive medical therapy plus CABG and 303 to receive medical therapy alone. A total of 178 of 487 patients with viable myocardium (37%) and 58 of 114 patients without viable myocardium (51%) died (hazard ratio for death among patients with viable myocardium, 0.64; 95% confidence interval [CI], 0.48 to 0.86; P=0.003). However, after adjustment for other baseline variables, this association with mortality was not significant (P=0.21). There was no significant interaction between viability status and treatment assignment with respect to mortality (P=0.53).

CONCLUSIONS:

The presence of viable myocardium was associated with a greater likelihood of survival in patients with coronary artery disease and left ventricular dysfunction, but this relationship was not significant after adjustment for other baseline variables. The assessment of myocardial viability did not identify patients with a differential survival benefit from CABG, as compared with medical therapy alone. (Funded by the National Heart, Lung, and Blood Institute; STICH ClinicalTrials.gov number, NCT00023595.).

PMID:
21463153
PMCID:
PMC3290901
DOI:
10.1056/NEJMoa1100358
[Indexed for MEDLINE]
Free PMC Article

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