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J Asian Nat Prod Res. 2011 Apr;13(4):290-6. doi: 10.1080/10286020.2011.554828.

Synthesis and biological evaluation of bilobol and adipostatin A.

Author information

1
Department of Materials & Life Sciences, Faculty of Science & Technology, Sophia University, Tokyo, Japan.

Abstract

Concise total synthesis of bilobol 5-pentadecenylresorcinol (1), isolated from Gingko biloba fruits, has been achieved in 10 steps with 51% overall yield from 3,5-dihydroxybenzoic acid (3). Adipostatin A (2), isolated from the fruits as well as from Streptomyces cyaneus 2299-SV1, has also been synthesized in two steps from methylated bilobol (10). The structure-activity relationship study of synthetic products was described by means of cytotoxic assay against human KB carcinoma cell lines.

PMID:
21462031
DOI:
10.1080/10286020.2011.554828
[Indexed for MEDLINE]

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