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Gastric Cancer. 2011 Aug;14(3):242-8. doi: 10.1007/s10120-011-0034-4. Epub 2011 Apr 2.

p53 codon 72 polymorphism in patients with gastric and colorectal cancer in a Korean population.

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1
Department of Preventive Medicine, Chonnam National University Medical School, 5, Hak 1-dong, Dong-gu, Gwangju, 501-746, South Korea.

Erratum in

  • Gastric Cancer. 2011 Aug;14(3):248.

Abstract

BACKGROUND:

The common p53 codon 72 polymorphism has been investigated as a risk factor for cancer in different populations; however, the results have been inconsistent. This study investigated the risk of developing gastric or colorectal cancer associated with the p53 codon 72 polymorphism in a Korean population.

METHODS:

We conducted a large-scale case-control study that included 2,213 gastric cancer patients; 1,829 colorectal cancer patients; and 1,700 healthy controls. Genotyping was performed with real-time polymerase chain reaction (PCR), using a TaqMan single-nucleotide polymorphism (SNP) genotyping assay.

RESULTS:

The frequencies of Arg/Arg, Arg/Pro, and Pro/Pro genotypes of the p53 codon 72 polymorphism were 43.3, 42.0, and 13.0% in the gastric cancer patients; 40.5, 45.0, and 14.0% in the colorectal cancer patients; and 43.2, 45.6, and 11.2% in the controls, respectively. The Pro/Pro genotype was associated with an increased risk of gastric [age- and sex-adjusted odds ratio (OR) = 1.25, 95% confidence interval (CI) = 1.01-1.56, P = 0.04] and colorectal cancer (OR = 1.36, 95% CI = 1.07-1.72, P = 0.01). There were no significant interactions between the p53 codon 72 polymorphism and smoking or drinking.

CONCLUSIONS:

Our results suggest that the Pro/Pro genotype is associated with modest increases in the risks of gastric cancer and colorectal cancer in a Korean population.

PMID:
21461655
DOI:
10.1007/s10120-011-0034-4
[Indexed for MEDLINE]
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