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Parkinsonism Relat Disord. 2011 Jun;17(5):379-81. doi: 10.1016/j.parkreldis.2011.03.003. Epub 2011 Apr 2.

Valproate for the treatment of medication-induced impulse-control disorders in three patients with Parkinson's disease.

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Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.


Impulse-control disorders (ICDs) are becoming more commonly recognized in the Parkinson disease (PD) population. To date, there are no definitive methods of treating dopamine dysregulation syndromes in PD patients. We sought to uncover an effective treatment option for future study. We report a series of 3 PD patients with ICDs who were effectively treated with valproate. Based on these encouraging preliminary observations, future controlled clinical trials investigating the efficacy of valproate for ICDs in PD are recommended.

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