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J Magn Reson. 2011 Jun;210(2):233-7. doi: 10.1016/j.jmr.2011.03.012. Epub 2011 Mar 17.

Effect of gradient pulse duration on MRI estimation of the diffusional kurtosis for a two-compartment exchange model.

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Department of Radiology, New York University School of Medicine, 660 First Avenue, New York, NY 10016-3295, USA.


Hardware constraints typically require the use of extended gradient pulse durations for clinical applications of diffusion-weighted magnetic resonance imaging (DW-MRI), which can potentially influence the estimation of diffusion metrics. Prior studies have examined this effect for the apparent diffusion coefficient. This study employs a two-compartment exchange model in order to assess the gradient pulse duration sensitivity of the apparent diffusional kurtosis (ADK), a quantitative index of diffusional non-Gaussianity. An analytic expression is derived and numerically evaluated for parameter ranges relevant to DW-MRI of brain. It is found that the ADK differs from the true diffusional kurtosis by at most a few percent. This suggests that ADK estimates for brain may be robust with respect to changes in pulse gradient duration.

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