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Trends Neurosci. 2011 Jun;34(6):316-25. doi: 10.1016/j.tins.2011.03.001. Epub 2011 Apr 2.

Regulation of neural process growth, elaboration and structural plasticity by NF-κB.

Author information

1
Cardiff School of Biosciences, University of Cardiff, Biomedical Sciences Building 3, Cardiff CF10 3AT, UK.

Abstract

The nuclear factor-kappa B (NF-κB) family of transcription factors has recently emerged as a major regulator of the growth and elaboration of neural processes. NF-κB signaling has been implicated in controlling axon initiation, elongation, guidance and branching and in regulating dendrite arbor size and complexity during development and dendritic spine density in the adult. NF-κB is activated by a variety of extracellular signals, and either promotes or inhibits growth depending on the phosphorylation status of the p65 NF-κB subunit. These novel roles for NF-κB, together with recent evidence implicating NF-κB in the regulation of neurogenesis in the embryo and adult, have important implications for neural development and for learning and memory in the mature nervous system.

PMID:
21459462
PMCID:
PMC3115056
DOI:
10.1016/j.tins.2011.03.001
[Indexed for MEDLINE]
Free PMC Article

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