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Cell Metab. 2011 Apr 6;13(4):361-366. doi: 10.1016/j.cmet.2011.03.010.

Unraveling the biological roles of reactive oxygen species.

Author information

1
MRC Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
2
Department of Medical Biophysics and Biochemistry, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
3
Max Planck Institute for Biology of Ageing, Gleueler Straße 50a, 50931 Köln, Germany.
4
National University of Singapore, University Hall, Lee Kong Chian Wing, UHL #05-02G, 21 Lower Kent Ridge Road, Singapore 119077, Republic of Singapore.
5
Department of Chemistry, University of California at Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
6
Department of Biophysics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA; Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
7
Division of Life and Pharmaceutical Sciences, Ewha Womans University, Science Building C, Room 103, 11-1 Daehyun-dong, Seodaemun-ku, Seoul 120-750, Korea.
8
Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry CV2 2DX, UK.
9
Department of Genetics, Evolution, and Environment, Institute of Healthy Ageing, University College London, Gower Street, London WC1E 6BT, UK.
10
Gothenburg University, 405 30 Göteborg, Sweden.
11
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia.
12
Northwestern University, Chicago, IL 60611, USA.
13
Department of Pathology, University of Otago, Christchurch 8011, New Zealand.

Abstract

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.

PMID:
21459321
PMCID:
PMC4445605
DOI:
10.1016/j.cmet.2011.03.010
[Indexed for MEDLINE]
Free PMC Article
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