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Cell Metab. 2011 Apr 6;13(4):355-6. doi: 10.1016/j.cmet.2011.03.003.

Is growth hormone resistance/IGF-1 reduction good for you?

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1
Division of Endocrinology, Diabetes and Bone Disease, Samuel Bronfman Department of Medicine, Mount Sinai Medical Center, New York, NY 10029, USA.

Abstract

GH, IGF-1, and insulin are emerging as important and independent mediators of tumor development and aging. Two recent studies report that humans with GH-receptor deficiency are protected from developing cancer through alterations in GH, IGF-1, and insulin signaling, decreasing the susceptibility of cells to DNA damage and abnormal proliferation.

PMID:
21459318
DOI:
10.1016/j.cmet.2011.03.003
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