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Can J Cardiol. 2011 Mar-Apr;27(2):262.e15-20. doi: 10.1016/j.cjca.2010.12.034.

Midterm outcomes and quality of life of aortic root replacement: mechanical vs biological conduits.

Author information

1
The University of Maryland School of Medicine, Baltimore, MD, USA.

Abstract

BACKGROUND:

Aortic root replacement is a complex operation for severe aortic root pathology such as aneurysms and dissections with concomitant aortic valve disease. Biological and mechanical valve conduits are available.

METHODS:

Early and midterm results were analyzed in patients undergoing aortic root replacement. From January 1, 1998, to May 31, 2007, 144 patients underwent aortic root replacement (Bentall procedures) with either a mechanical (n = 51) or a biological (n = 93) valve conduit. Cox proportional hazard analysis was used to determine whether valve type was an independent predictor of all-cause mortality, and analysis of covariance was used to compare general and disease-specific health-related quality-of-life scores.

RESULTS:

Operative mortality was 2.1%. Median follow-up time was 40 months; 1- and 5-year survival rates for the mechanical group were 96.0% and 89.0%, respectively, vs 93.0% and 84.0% for the biological group. Valve type was not predictive of all-cause mortality, and valve-related complications were not significantly different between groups. At follow-up, 31.5% of patients in the biological group were on anticoagulant. General and disease-specific health-related quality-of-life scores were not significantly different between groups.

CONCLUSIONS:

Aortic root replacement with either mechanical or biological valved conduits is a safe procedure. Morbidity, mortality, and adverse quality of life were not associated with the type of valve conduit. Further studies are required to assess long-term durability of biological valve conduits used for aortic root replacement.

PMID:
21459276
DOI:
10.1016/j.cjca.2010.12.034
[Indexed for MEDLINE]

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