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Cell. 2011 Apr 1;145(1):30-8. doi: 10.1016/j.cell.2011.03.020.

Genetic interactions in cancer progression and treatment.

Author information

1
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK. alan.ashworth@icr.ac.uk

Abstract

As cancer cell genomes are unveiled at a breathtaking pace, the genetic principles at play in cancer are emerging in all their complexity, prompting the assessment of classical genetic interaction models. Here, we discuss the implications of these findings for cancer progression and heterogeneity and for the development of new therapeutic approaches.

PMID:
21458666
DOI:
10.1016/j.cell.2011.03.020
[Indexed for MEDLINE]
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