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Trends Endocrinol Metab. 2011 Jul;22(7):266-74. doi: 10.1016/j.tem.2011.02.008. Epub 2011 Mar 31.

Endoplasmic reticulum stress and pancreatic β-cell death.

Author information

1
Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

Abstract

In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total protein production in these cells. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR), which influences both life and death decisions in cells. β-cell loss is a pathological component of both type 1 and type 2 diabetes, and recent findings suggest that ER stress is involved. In this review, we address the transition from the physiological ER stress response to the pathological response, and explore the mechanisms of ER stress-mediated β-cell loss during the progression of diabetes.

PMID:
21458293
PMCID:
PMC3130122
DOI:
10.1016/j.tem.2011.02.008
[Indexed for MEDLINE]
Free PMC Article

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