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Bioorg Med Chem. 2011 Apr 15;19(8):2625-32. doi: 10.1016/j.bmc.2011.03.009. Epub 2011 Mar 12.

Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum.

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1
College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.

Abstract

Four new cembranoids, namely laevigatol A-D (1-4), and six known metabolites (5-10), were isolated from the Vietnamese soft coral Lobophytum laevigatum. The structures of these compounds were elucidated by extensive spectroscopic analyses, and the absolute stereochemistry of 1 was determined using the modified Mosher's method. Compounds 5, and 7-10 exhibited cytotoxic activity against selected human cancer cell lines. Compounds 1, 2, 8, and 9 showed dose-dependent inhibitory effects on the TNFα-induced NF-κB transcriptional activity in Hep-G2 cells. Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level.

PMID:
21458279
DOI:
10.1016/j.bmc.2011.03.009
[Indexed for MEDLINE]
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