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Bioorg Med Chem Lett. 2011 May 15;21(10):3163-7. doi: 10.1016/j.bmcl.2011.02.096. Epub 2011 Mar 4.

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Author information

1
Department of Chemistry, MSD, Newhouse, Lanarkshire ML1 5SH, UK. susannapier67@googlemail.com

Abstract

The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.

PMID:
21458261
DOI:
10.1016/j.bmcl.2011.02.096
[Indexed for MEDLINE]

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