Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2011 May 15;21(10):3113-6. doi: 10.1016/j.bmcl.2011.03.017. Epub 2011 Mar 30.

Triamino pyrimidines and pyridines as histamine H(4) receptor modulators.

Author information

1
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. smeduna@its.jnj.com

Abstract

Two series of triamino pyrimidines and a series of triamino pyridines have been synthesized and their structure-activity relationships evaluated for activity at the H(4) receptor in competitive binding and functional assays. Small structural changes in these three hetereoaromatic cores influenced the functional activity of these compounds.

PMID:
21458260
DOI:
10.1016/j.bmcl.2011.03.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center