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FEBS Lett. 2011 Apr 20;585(8):1127-34. doi: 10.1016/j.febslet.2011.03.057. Epub 2011 Mar 30.

The membrane localization of Ras2p and the association between Cdc25p and Ras2-GTP are regulated by protein kinase A (PKA) in the yeast Saccharomyces cerevisiae.

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  • 1Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Nankai District, Tianjin 300072, PR China.


The Saccharomyces cerevisiae Ras2p has been suggested to be a target in the feedback regulation of Ras-cAMP pathway. This work proves that the Ras2p localization is regulated by PKA activity, and that PKA down-regulates Ras2p activity and the protein association between Cdc25p and Ras2-GTP, which is due to a reduced Ras2-GEF Cdc25p activity. These results suggest that Ras2p localization and Ras2-GEF activity of Cdc25p play roles in the feedback regulation of Ras2p in the Ras-cAMP pathway.

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