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Arthritis Res Ther. 2011 Mar 17;13(2):207. doi: 10.1186/ar3251.

Abnormalities of T cell signaling in systemic lupus erythematosus.

Author information

1
Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. vmoulton@bidmc.harvard.edu

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production, contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy.

PMID:
21457530
PMCID:
PMC3132009
DOI:
10.1186/ar3251
[Indexed for MEDLINE]
Free PMC Article

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