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Breast Cancer Res. 2011 Mar 14;13(2):206. doi: 10.1186/bcr2831.

Signaling pathways in breast cancer metastasis - novel insights from functional genomics.

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  • 1Department of Molecular Biology, Washington Road, LTL 255, Princeton University, Princeton, NJ 08544, USA.

Abstract

The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis. Gene expression analyses of primary tumors have been used to predict metastatic propensity with high accuracy. Animal models of metastasis additionally offer a platform to experimentally dissect components of the metastasis genetic program. Recent integrated studies have synergized clinical bioinformatic analyses with advanced experimental methodology and begun to uncover the identities and dynamics of signaling programs driving breast cancer metastasis. Such functional genomics studies hold great promise for understanding the genetic basis of metastasis and improving therapeutics for advanced diseases.

PMID:
21457525
PMCID:
PMC3219178
DOI:
10.1186/bcr2831
[PubMed - indexed for MEDLINE]
Free PMC Article
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