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Indian J Pharmacol. 2011 Feb;43(1):56-9. doi: 10.4103/0253-7613.75671.

An evaluation of the antidiabetic effects of Elaeocarpus ganitrus in experimental animals.

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  • 1Department of Pharmaceutical Sciences and Technology, University Institute of Chemical Technology (UICT), Mumbai University, Matunga, Mumbai - 400 019, India.

Abstract

OBJECTIVE:

To evaluate the antidiabetic effects of the aqueous extract of Elaeocarpus ganitrus (EAG) in experimental animals.

MATERIALS AND METHODS:

The hypoglycemic activity of the EGA was evaluated in normoglycemic rats by single dose at three graded dose levels, viz. 250, 500 and 1000 mg/kg of body weight. Antihyperglycemic activity of the extract was also evaluated at the same dose levels in streptozotocin (STZ) (60 mg/kg, i.p.)-induced diabetic rats during a 30-day treatment period. Metformin (500 mg/kg) was used as the reference drug. Fasting blood glucose and lipid parameters, viz. triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were measured. Acute oral toxicity of the EGA extract was carried out in Swiss albino mice.

RESULTS:

In normoglycemic rats, EGA showed a significant (P < 0.01) hypoglycemic effect at 2 h. In STZ-induced diabetic rats, the EGA treatment significantly (P < 0.05) decreased the blood glucose level in a dose-dependent manner during the 30 days of treatment period. EGA modulated lipid profile changes in STZ-diabetic rats in a dose-dependant manner. In the acute oral toxicity study, EGA showed no mortality till the 5 g/kg dose in mice.

CONCLUSION:

The present investigation shows that EAG seeds has potential antidiabetic effects.

KEYWORDS:

Antihyperglycemic; Elaeocarpus ganitrus; diabetes; streptozotocin

PMID:
21455423
PMCID:
PMC3062122
DOI:
10.4103/0253-7613.75671
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