The compartment model was initialized, and the simulation was run in the same way as in . The model was initialized such that the system consisted of a population of Rp enclosed in a compartment. The simulation was first run with the mutation converting Rp into Dp disabled (

). After the system reached evolutionary equilibrium (), the mutation (

) was enabled. The resulting evolutionary dynamics are depicted in panel B to E. The left picture of each panel shows a snapshot of the simulation taken at different times as indicated above panels. The color coding is indicated in the upper left corner of the figure. DNA and RNA are not distinguished. The insets depict two-dimensional histogram of

and

. The right picture of each panel shows a snapshot with a different color coding, which indicates the value of

. Distinction is not made between Dp and Rp and between DNA and RNA. The insets depict a histogram of

with the same color coding as in the larger pictures that contain them. For the explanation of each panel, see the main text. The parameters were as follows:

(the volume threshold for division of compartments);

(the target volume is set to the number of internal replicators multiplied by

);

; the size of the CA is 512×512 squares; the other parameters were the same as in .