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Nat Rev Rheumatol. 2011 Apr;7(4):202-3. doi: 10.1038/nrrheum.2011.28.

Rheumatoid arthritis: Are ACPA-positive and ACPA-negative RA the same disease?

Author information

1
Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333ZA, The Netherlands. n.a.daha@lumc.nl

Abstract

Seemingly contrasting genetic backgrounds in anti-citrullinated-protein antibody (ACPA)-positive and ACPA-negative rheumatoid arthritis (RA) support the notion that these are in fact two distinct disease subsets, with different underlying pathogenesis, that might need tailored treatment strategies.

PMID:
21455249
DOI:
10.1038/nrrheum.2011.28
[Indexed for MEDLINE]

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