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J Biol Chem. 2011 May 27;286(21):18355-61. doi: 10.1074/jbc.R110.197061. Epub 2011 Mar 24.

Bookmarking the genome: maintenance of epigenetic information.

Author information

1
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

Abstract

Mitotic inheritance of gene function is obligatory to sustain biological control. Emerging evidence suggests that epigenetic mechanisms are linked to transmission of cell fate, lineage commitment, and maintenance of cellular phenotype in progeny cells. Mechanisms of epigenetic memory include gene silencing by DNA methylation, transcriptional regulation by histone modifications, regulation of gene expression by noncoding small RNA molecules, and retention of regulatory machinery on target gene loci for activation and repression. We will focus on the regulatory implications of epigenetic memory for physiological control and for the onset and progression of disease.

PMID:
21454629
PMCID:
PMC3099651
DOI:
10.1074/jbc.R110.197061
[Indexed for MEDLINE]
Free PMC Article

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