Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biol Chem. 2011 May 13;286(19):16533-40. doi: 10.1074/jbc.R111.227108. Epub 2011 Mar 25.

Structural insights into functional and pathological amyloid.

Author information

1
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. fshewmaker@usuhs.mil

Abstract

Amyloid is traditionally viewed as a consequence of protein misfolding and aggregation and is most notorious for its association with debilitating and chronic human diseases. However, a growing list of examples of "functional amyloid" challenges this bad reputation and indicates that many organisms can employ the biophysical properties of amyloid for their benefit. Because of developments in the structural studies of amyloid, a clearer picture is emerging about what defines amyloid structure and the properties that unite functional and pathological amyloids. Here, we review various amyloids and place them within the framework of the latest structural models.

PMID:
21454545
PMCID:
PMC3089495
DOI:
10.1074/jbc.R111.227108
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center