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Cardiovasc Revasc Med. 2011 Nov-Dec;12(6):367-74. doi: 10.1016/j.carrev.2011.02.001. Epub 2011 Mar 30.

Serum gamma glutamyl transferase: a novel biomarker for screening of premature coronary artery disease.

Author information

1
Department of Pathology, AMC, National University of Sciences and Technology, Rawalpindi, Pakistan.

Abstract

BACKGROUND:

We aimed to elucidate the association between gamma glutamyl transferase (GGT) activity with prevalence of premature coronary artery disease (CAD) in young Pakistani patients undergoing diagnostic coronary angiography.

METHODS:

A total of 218 young adults (age ≤ 45 years) underwent diagnostic angiography. Serum samples were taken from all the patients and analyzed for serum GGT activity, cholesterol and triglycerides.

RESULTS:

Coronary artery disease patients had significantly increased GGT activity (P = .001) and exhibited a significant positive correlation with blood pressure, cholesterol, blood glucose, and smoking and negative correlation with total antioxidant status (P < .01).

CONCLUSION:

The study revealed good diagnostic accuracy at cutoff of 35 U/L with a sensitivity of 92%, specificity of 81%, and diagnostic odds ratio of 48 in estimation of premature CAD in young Pakistanis.

PMID:
21454140
DOI:
10.1016/j.carrev.2011.02.001
[Indexed for MEDLINE]

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