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Curr Opin Plant Biol. 2011 Aug;14(4):358-64. doi: 10.1016/j.pbi.2011.03.007. Epub 2011 Mar 30.

Redox-based protein modifications: the missing link in plant immune signalling.

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University of Edinburgh, Institute of Molecular Plant Sciences, King's Buildings, Daniel Rutherford Building, Mayfield Rd, Edinburgh, EH9 3JR, United Kingdom.


Activation of plant immunity is associated with dramatic changes in the cellular redox status. Both oxidative and reductive bursts have been described that trigger a set of down stream responses resulting in reprogramming of the transcriptome and establishment of disease resistance. Nonetheless, how these redox changes are sensed and signal to downstream regulators remained a missing link in studies of plant immunity. Emerging evidence now indicates that pathogen-induced changes in the cellular redox environment are sensed by reactive cysteine residues of key regulatory proteins. Varying degrees of reversible, oxidative cysteine modifications control the activity, localization, protein-interaction and stability of regulatory proteins. These diverse effects on protein function make post-translational redox-based modifications potent modulators of plant immunity.

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