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Pediatr Clin North Am. 2011 Apr;58(2):315-26, ix. doi: 10.1016/j.pcl.2011.02.008.

Clinical presentations of food allergy.

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Division of Allergy and Immunology, Center for Cancer and Blood Disorders, Children's National Medical Center, 111 Michigan Avenue, North West, Washington, DC 20010, USA.


Food allergies are immune-mediated responses to food proteins. Because of differences in the underlying immunologic mechanisms, there are varying clinical presentations of food allergy. This article discusses the manifestations of IgE-mediated disorders, including urticaria and angioedema, rhinoconjunctivitis, asthma, gastrointestinal anaphylaxis, generalized anaphylaxis, food-dependent exercise-induced anaphylaxis, and oral allergy syndrome. It also reviews the presentations of mixed IgE- and cell-mediated disorders, including atopic dermatitis and eosinophilic gastrointestinal disorders. Finally, the manifestations of cell-mediated food allergies are discussed, including dietary protein-induced proctitis and proctocolitis, food protein-induced enterocolitis syndrome, celiac disease, and food-induced pulmonary hemosiderosis.

[Indexed for MEDLINE]

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