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Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis.


San Rafael (CA): Morgan & Claypool Life Sciences; 2010.
Integrated Systems Physiology: from Molecule to Function to Disease.

Author information

Michael E. DeBakey VA Medical Center and Baylor College of Medicine


Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions.

Copyright © 2010 by Morgan & Claypool Life Sciences.

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