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Chem Commun (Camb). 2011 May 14;47(18):5184-6. doi: 10.1039/c1cc10167f. Epub 2011 Mar 30.

Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents.

Author information

  • 1Department of Chemistry, University of Ulsan, Ulsan 680-749, Republic of Korea.

Abstract

Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.

PMID:
21451846
PMCID:
PMC3441832
DOI:
10.1039/c1cc10167f
[PubMed - indexed for MEDLINE]
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