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J Magn Reson Imaging. 2011 Apr;33(4):974-9. doi: 10.1002/jmri.22489.

Quantification of vertebral bone marrow fat content using 3 Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis.

Author information

  • 1Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, USA. xiaojuan.li@ucsf.edu

Abstract

PURPOSE:

To determine the reproducibility of proton MR spectroscopy ((1) H-MRS) for assessing vertebral bone marrow adiposity at 3 Tesla (T); to evaluate variation of marrow adiposity at different vertebral levels; and to demonstrate the feasibility of using (1) H-MRS at 3T for evaluating marrow adiposity in subjects with low bone density.

MATERIALS AND METHODS:

Single voxel MRS was acquired at vertebral body L1 to L4 at 3T in 51 postmenopausal females including healthy controls (n = 13) and patients with osteoporosis/osteopenia (n = 38). Marrow fat contents were compared between vertebral levels and between groups using analysis of variance (ANOVA). Six subjects were scanned twice to evaluate technique reproducibility.

RESULTS:

The average coefficient of variation of vertebral marrow fat content quantification was 1.7%. Marrow fat content significantly increased from L1 to L4. The average fat content was significantly elevated in patients with osteoporosis/osteopenia compared with controls, adjusted for age and body mass index (P < 0.05).

CONCLUSION:

In vivo MRS at high field strength provides reliable measurement of marrow adiposity with excellent reproducibility and can be a valuable tool for providing complementary information on bone quality and potentially also fracture risk.

PMID:
21448966
PMCID:
PMC3072841
DOI:
10.1002/jmri.22489
[PubMed - indexed for MEDLINE]
Free PMC Article
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