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J Neural Transm (Vienna). 2011 Oct;118(10):1453-60. doi: 10.1007/s00702-011-0631-8. Epub 2011 Mar 30.

Pedunculopontine stimulation from primate to patient.

Author information

1
Oxford Functional Neurosurgery, Department of Neurological Surgery, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK. eacp@eacp.co.uk

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel neurosurgical therapy developed to address symptoms of gait freezing and postural instability in Parkinson's disease and related disorders. Here we summarise our non-human primate investigations of relevance to our surgical targeting of the PPN and relate the primate research to initial clinical experience of PPN DBS.

PMID:
21448675
DOI:
10.1007/s00702-011-0631-8
[Indexed for MEDLINE]

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