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[CD4+CD25+Foxp3+ T lymphocytes: naturally occuring regulatory T cells].

[Article in Polish]

Author information

1
Zaklad Immunologii, Katedra Immunologii, Gdanski Uniwersytet Medyczny, Gdansk. akinomab@gumed.edu.pl

Abstract

The mechanism that plays an essential role in immunosuppression and regulation is the presence of naturally occurring regulatory T cells (Tregs), which comprise 5-10% of peripheral CD4+ lymphocytes. They are characterized by the constant and high expression of the α subunit of IL-2 receptor (CD25), which makes them different from conventional, CD4+ and CD8+ lymphocytes, which express this molecule at lower level only during the activation state. The function of regulatory T cells is to inhibit proliferation as well as cytokine production by effector CD4+CD25- lymphocytes. They are also able to suppress CD8+ T cells, monocytes, NK cells, dendritic cells and B cells. The transcription factor Foxp3 is the key regulatory gene for the development and function of regulatory T lymphocytes. Its expression is limited to CD4+CD25high T cells at both mRNA and protein levels. Foxp3 is a specific indicator of suppressive activity of Tregs and it acts as repressor as well as activator of transcription.

PMID:
21447271
[Indexed for MEDLINE]
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