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J Matern Fetal Neonatal Med. 2012 Feb;25(2):133-7. doi: 10.3109/14767058.2011.564242. Epub 2011 Mar 28.

The association between first trimester micronutrient intake, MTHFR genotypes, and global DNA methylation in pregnant women.

Author information

1
Department of Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA. michele.lamerrill@mssm.edu

Abstract

OBJECTIVE:

Our aim was to evaluate possible associations between consumption of micronutrients involved in one-carbon metabolism, MTHFR genotypes, and global DNA methylation in pregnant women.

METHODS:

A semi-quantitative dietary questionnaire was administered to 195 women during their first trimester in Morelos, Mexico. Two functional polymorphisms of the key folate-metabolizing gene, i.e. MTHFR 677 C>T and 1298 A>C, as well as global DNA methylation were assessed in peripheral blood drawn during the interview.

RESULTS:

Independent of maternal age and caloric intake, vitamin B(6) deficiency was associated with 1.8 fold increased risk of hypomethylation in women carrying the MTHFR 677 T allele.

CONCLUSIONS:

There exists a subpopulation that is more susceptible to B vitamin deficiencies.

PMID:
21443409
PMCID:
PMC3279137
DOI:
10.3109/14767058.2011.564242
[Indexed for MEDLINE]
Free PMC Article
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