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Head Neck Pathol. 2011 Dec;5(4):389-94. doi: 10.1007/s12105-011-0257-z. Epub 2011 Mar 26.

EBV-positive plasmacytoma of the submandibular gland--report of a rare case with molecular genetic characterization.

Author information

1
Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074, Singapore.

Abstract

Plasmacytomas are differentiated plasma cell tumors that present as a mass lesion in osseous or extraosseous sites. Although the most common site for extramedullary plasmacytomas (EMP) is in the upper respiratory tract, plasmacytomas initially presenting as salivary gland masses are very uncommon. We describe a case of an EBV-positive plasmacytoma presenting as a 7.7 cm submandibular mass in an elderly immunocompetent man which displayed an abundance of "naked nuclei" on fine needle aspiration cytology. The tumor showed lambda light chain restriction and positive expression for CD38, MUM1 and EBER. Subsequent investigation for myeloma revealed absence of M-protein and end-organ damage, except for a lytic lesion in the radial bone. An extensive fluorescent in situ hybridization analysis showed the tumor to be negative for the t(4;14) FGFR3/IGH translocation as well as translocations involving the IGH, IGL, IGK, CCND1, BCL2, BCL6 and C-MYC genes. KRAS genetic analysis did not reveal any mutations of codons 12, 13 and 61.

PMID:
21442194
PMCID:
PMC3210227
DOI:
10.1007/s12105-011-0257-z
[Indexed for MEDLINE]
Free PMC Article

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