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Pharmacol Rep. 2011;63(1):165-8.

Endocannabinoid system protects against cryptogenic seizures.

Author information

1
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, P.O.B. 9104, 6500 HE Nijmegen, The Netherlands. t.vanrijn@donders.ru.nl

Abstract

Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures.

PMID:
21441624
[Indexed for MEDLINE]
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