Abstract
Metformin is an oral antidiabetic, which is frequently used in the treatment of type II diabetes mellitus. Serious side effects may be seen during the administration of high doses of metformin. Two cases of lactic acidosis due to ingestion of high dose metformin for suicidal purposes have been presented here; in both cases, clinical improvement was seen with bicarbonate hemodialysis.
MeSH terms
-
Acidosis, Lactic / chemically induced
-
Acidosis, Lactic / metabolism
-
Acidosis, Lactic / therapy*
-
Adolescent
-
Bicarbonates / administration & dosage*
-
Diabetes Mellitus, Type 2 / drug therapy*
-
Diabetes Mellitus, Type 2 / metabolism
-
Dialysis Solutions
-
Humans
-
Hypoglycemic Agents / toxicity*
-
Lactic Acid / blood
-
Male
-
Metformin / toxicity*
-
Renal Dialysis / methods*
-
Suicide, Attempted
-
Treatment Outcome
Substances
-
Bicarbonates
-
Dialysis Solutions
-
Hypoglycemic Agents
-
Lactic Acid
-
Metformin