Format

Send to

Choose Destination
Trends Parasitol. 2011 Jun;27(6):254-63. doi: 10.1016/j.pt.2011.02.006. Epub 2011 Mar 26.

Tissue destruction and invasion by Entamoeba histolytica.

Author information

1
Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA.

Abstract

Entamoeba histolytica is the causative agent of amebiasis, a disease that is a major source of morbidity and mortality in the developing world. The potent cytotoxic activity of the parasite appears to underlie disease pathogenesis, although the mechanism is unknown. Recently, progress has been made in determining that the parasite activates apoptosis in target cells and some putative effectors have been identified. Recent studies have also begun to unravel the host genetic determinants that influence infection outcome. Thus, we are beginning to get a clearer picture of how this parasite manages to infect, invade and ultimately inflict devastating tissue destruction.

PMID:
21440507
PMCID:
PMC3104091
DOI:
10.1016/j.pt.2011.02.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center