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Biochim Biophys Acta. 2011 Nov;1811(11):961-9. doi: 10.1016/j.bbalip.2011.03.004. Epub 2011 Mar 29.

Imaging mass spectrometry for lipidomics.

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1
Department of Molecular Anatomy, Hamamatsu University School of Medicine, Shizuoka, Japan.

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful tool that enables the simultaneous detection and identification of biomolecules in analytes. MALDI-imaging mass spectrometry (MALDI-IMS) is a two-dimensional MALDI-MS technique used to visualize the spatial distribution of biomolecules without extraction, purification, separation, or labeling of biological samples. This technique can reveal the distribution of hundreds of ion signals in a single measurement and also helps in understanding the cellular profile of the biological system. MALDI-IMS has already revealed the characteristic distribution of several kinds of lipids in various tissues. The versatility of MALDI-IMS has opened a new frontier in several fields, especially in lipidomics. In this review, we describe the methodology and applications of MALDI-IMS to biological samples.

PMID:
21440085
DOI:
10.1016/j.bbalip.2011.03.004
[Indexed for MEDLINE]
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