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Food Chem Toxicol. 2011 Jun;49(6):1426-30. doi: 10.1016/j.fct.2011.03.037. Epub 2011 Mar 31.

Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice.

Author information

1
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, Netherlands.

Abstract

BACKGROUND:

Pomegranate seed oil has been shown to protect against diet induced obesity and insulin resistance.

OBJECTIVE:

To characterize the metabolic effects of punicic acid on high fat diet induced obesity and insulin resistance.

DESIGN:

High-fat diet or high-fat diet with 1% Pomegranate seed oil (PUA) was fed for 12 weeks to induce obesity and insulin resistance. We assessed body weight and composition (pSABRE DEXA-scan), energy expenditure (Columbus Instruments) and insulin sensitivity at the end of the 12 weeks.

RESULTS:

PSO intake resulted in a lower body weight, 30.5±2.9 vs 33.8±3.2 g PSO vs HFD respectively, p=0.02, without affecting food intake or energy expenditure. The lower body weight was fully explained by a decreased body fat mass, 3.3±2.3 vs 6.7±2.7 g for PSO and HFD fed mice, respectively, p=0.02. Insulin clamps showed that PSO did not affect liver insulin sensitivity but clearly improved peripheral insulin sensitivity, 164±52% vs 92±24% for PSO and HFD fed mice respectively, p=0.01.

CONCLUSIONS:

We conclude that dietary PSO ameliorates high-fat diet induced obesity and insulin resistance in mice, independent of changes in food intake or energy expenditure.

PMID:
21440024
DOI:
10.1016/j.fct.2011.03.037
[Indexed for MEDLINE]

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