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Mitochondrion. 2011 Jul;11(4):587-600. doi: 10.1016/j.mito.2011.03.008. Epub 2011 Mar 23.

Hsp90 and mitochondrial proteases Yme1 and Yta10/12 participate in ATP synthase assembly in Saccharomyces cerevisiae.

Author information

1
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA.

Abstract

Hsc82 and Hsp82, the Hsp90 family proteins of yeast, are both required for fermentative growth at 37°C. Inactivation of either of the mitochondrial AAA proteases, Yme1 or Yta10/12, allows fermentative growth of hsc82∆ or hsp82∆ strains at 37°C. Genetic evidence indicates interaction of Hsc82/Hsp82 with the Yme1 and Yta10/Yta12 complexes in promoting F(1)F(o)-ATPase activity, with Hsc82 specifically required for F(1)-ATPase assembly. A previously reported mutation in Rpt3, one of the six ATPases of the proteasome, suppresses yme1∆ phenotypes and increases transcription of HSC82 but not HSP82. These genetic interactions describe a functional role for Hsp90 proteins in mitochondrial biogenesis.

PMID:
21439406
PMCID:
PMC3109234
DOI:
10.1016/j.mito.2011.03.008
[Indexed for MEDLINE]
Free PMC Article

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