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J Nat Prod. 2011 Apr 25;74(4):857-61. doi: 10.1021/np100775a. Epub 2011 Mar 25.

Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells.

Author information

1
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019, USA.

Abstract

Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

PMID:
21438584
DOI:
10.1021/np100775a
[Indexed for MEDLINE]

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