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Macromol Biosci. 2011 Jun 14;11(6):779-88. doi: 10.1002/mabi.201100050. Epub 2011 Mar 22.

PAA-derived gold nanorods for cellular targeting and photothermal therapy.

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1
Graduate Field of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA. dk322@cornell.edu

Abstract

A single-step LbL procedure to functionalize CTAB-capped GNRs via electrostatic self-assembly is reported. This approach allows for consistent biomolecule/GNR coupling using standard carboxyl-amine conjugation chemistry. The focus is on cancer-targeting biomolecule/GNR conjugates and selective photothermal destruction of cancer cells by GNR-mediated hyperthermia and NIR light. GNRs were conjugated to a single-chain antibody selective for colorectal carcinoma cells and used as probes to demonstrate photothermal therapy. Selective targeting and GNR uptake in antigen-expressing SW 1222 cells were observed using fluorescence microscopy. Selective photothermal therapy is demonstrated using SW 1222 cells, where >62% cell death was observed after cells are treated with targeted A33scFv-GNRs.

PMID:
21438153
DOI:
10.1002/mabi.201100050
[Indexed for MEDLINE]
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