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Photochem Photobiol Sci. 2011 May;10(5):751-8. doi: 10.1039/c0pp00345j. Epub 2011 Mar 24.

The immunosuppressive side of PDT.

Author information

1
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA. pmroz@partners.org

Abstract

Photodynamic therapy (PDT) is a promising novel therapeutic procedure for the management of a variety of solid tumors and many non-malignant diseases. PDT has been described as having a significant effect on the immune system, which may be either immunostimulatory or, in some circumstances, immunosuppressive. The immunosuppressive effects of PDT have nearly all been concerned with the suppression of the contact hypersensitivity reaction in mice. Here, we review the immunosuppressive aspects of PDT treatment and discuss some additional mechanisms that may be involved.

PMID:
21437314
PMCID:
PMC3441049
DOI:
10.1039/c0pp00345j
[Indexed for MEDLINE]
Free PMC Article

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