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J Biomed Biotechnol. 2011;2011:939023. doi: 10.1155/2011/939023. Epub 2011 Mar 7.

The animal model of spinal cord injury as an experimental pain model.

Author information

1
Department of Anesthesiology & Intensive Care, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. anakae@anes.med.osaka-u.ac.jp

Abstract

Pain, which remains largely unsolved, is one of the most crucial problems for spinal cord injury patients. Due to sensory problems, as well as motor dysfunctions, spinal cord injury research has proven to be complex and difficult. Furthermore, many types of pain are associated with spinal cord injury, such as neuropathic, visceral, and musculoskeletal pain. Many animal models of spinal cord injury exist to emulate clinical situations, which could help to determine common mechanisms of pathology. However, results can be easily misunderstood and falsely interpreted. Therefore, it is important to fully understand the symptoms of human spinal cord injury, as well as the various spinal cord injury models and the possible pathologies. The present paper summarizes results from animal models of spinal cord injury, as well as the most effective use of these models.

PMID:
21436995
PMCID:
PMC3062973
DOI:
10.1155/2011/939023
[Indexed for MEDLINE]
Free PMC Article
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