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Pan Afr Med J. 2010 Jul 28;6:4.

Neuroendocrine differentiation in a case of cervical cancer.

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Department of Pathology, Damanhour National Medical Institute, General Organization of Teaching Hospitals and Institutes, Egypt.


Neuroendocrine neoplasms may occur in the uterine cervix, although rarely; it accounts for 0.5-1% of all malignant tumors of the uterine cervix. A case report of an Ethiopian female presented at the Gynecology Out-Patient Clinic at Jimma University Hospital, complaining from irregular vaginal bleeding over the previous three months. Clinically there was a cauliflower cervical mass; histopathologically it was formed of sheets of small cell tumor; that further showed neuroendocrine differentiation, as demonstrated by chromogranin-A positivity. It is important to differentiate small cell carcinoma from other malignant tumors of the uterine cervix. Morphological features play an important role in making a diagnosis and the immunohistochemistry study can offer an additional useful assistance.


Cervical cancer; cervix; chromogranine A; small cell carcinoma

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