Format

Send to

Choose Destination
Trends Immunol. 2011 May;32(5):225-31. doi: 10.1016/j.it.2011.02.006. Epub 2011 Mar 23.

T cell responses during influenza infection: getting and keeping control.

Author information

1
Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

The 2009 influenza pandemic highlighted the threat that type A influenza poses to human health. Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution of the host immune response to virus elimination and the development of lung injury. This review focuses on the T cell arm of the adaptive host immune response to influenza. We assess recent developments in the understanding of how primary influenza virus-specific T cell responses are induced by antigen-presenting cells, the interaction of activated effector T cells with antigen-bearing cells in the infected lungs. Also examined is the contribution of influenza-specific effector T cells to the development and control of lung injury and inflammation during infection.

PMID:
21435950
PMCID:
PMC3090469
DOI:
10.1016/j.it.2011.02.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center