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Neurosurg Clin N Am. 2011 Apr;22(2):253-68, ix. doi: 10.1016/

Diffusion tractography: methods, validation and applications in patients with neurosurgical lesions.

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  • 1Centre de NeuroImagerie de Recherche-CENIR, Groupe Hospitalier Pitié-Salpêtrière 47-83, Bd de l'Hôpital, 75013 Paris, France.


Diffusion tensor imaging (DTI) tractography is increasingly used in presurgical mapping in tumors located in eloquent areas since it is the only non invasive technique that permits in vivo dissection of white matter tracts. Concordance between the DTI tracts and subcortical electrical intraoperative mapping is high, and DTI tractography has proven useful to guide surgery. However, it presents limitations due to the technique and the tumor, which must be known before using the images in the operative room. This review focuses on the possibilities and limits of DTI imaging in intraoperative tumoral mapping and presents an overview of current knowledge.

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