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Org Lett. 2011 Apr 15;13(8):2138-41. doi: 10.1021/ol200617f. Epub 2011 Mar 24.

Nickel-catalyzed reductive cross-coupling of unactivated alkyl halides.

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1
Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China.

Abstract

A Ni-catalyzed reductive approach to the cross-coupling of two unactivated alkyl halides has been successfully developed. The reaction works efficiently for primary and secondary halides, with at least one being bromide. The mild reaction conditions allow for excellent functional group tolerance and provide the C(sp(3))-C(sp(3)) coupling products in moderate to excellent yields.

PMID:
21434609
DOI:
10.1021/ol200617f

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