Format

Send to

Choose Destination
See comment in PubMed Commons below
Methods Mol Biol. 2011;714:447-66. doi: 10.1007/978-1-61779-005-8_27.

Identifying and searching for conserved RNA localisation signals.

Author information

1
Department of Biochemistry, University of Oxford, Oxford, UK.

Abstract

RNA localisation is an important mode of delivering proteins to their site of function. Cis-acting signals within the RNAs, which can be thought of as zip-codes, determine the site of localisation. There are few examples of fully characterised RNA signals, but the signals are thought to be defined through a combination of primary, secondary, and tertiary structures. In this chapter, we describe a selection of computational methods for predicting RNA secondary structure, identifying localisation signals, and searching for similar localisation signals on a genome-wide scale. The chapter is aimed at the biologist rather than presenting the details of each of the individual methods.

PMID:
21431757
PMCID:
PMC3082378
DOI:
10.1007/978-1-61779-005-8_27
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Support Center