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Toxicol Int. 2011 Jan;18(1):44-6. doi: 10.4103/0971-6580.75854.

A Study of Certain Herbs Against Chlorpyrifos-induced Changes in Lipid and Protein Profile in Poultry.

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1
Department of Pharmacology and Toxicology, College of Veterinary Science, Hyderabad - 30, India.

Abstract

A total of 225 male broiler chicks (Cobb strain) of day-old age were procured for the study. The chicks were randomly divided into 15 groups consisting of 15 chicks in each group. Group 1 was maintained as basal diet control and group 2 on chlorpyrifos (CPS) at 100 ppm in feed throughout 6 wk as iron toxic control without any treatment. Groups 3-15 were maintained on CPS at 100 ppm in feed for the 4 wk (28 days) of study and thereafter administered with different herbs and their combinations for remaining 2 wk. The blood samples were drawn from wing vein on 28(th) day and 42(nd) day from the birds in each group for the estimation of lipid and protein profiles. The birds were sacrificed at the end of 6(th) week and liver tissues were collected for histological examination. The concentrations of total cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, total protein, albumin and globulins and the A/G ratio were increased significantly (P<;0.05) in toxic groups (2-15), while high density lipoprotein (HDL) cholesterol was significantly (P<;0.05) decreased at the end of 4(th) week. However, following supplementation of herbs and herbal combinations, the values of lipid and protein profile in groups 3-15 revived toward normal at the end of 6(th) week. Histopathology of liver in CPS toxic control (group 2) revealed areas of degeneration, while groups 3-15 that were treated with herbs and their combinations exhibited these changes in a milder form, indicating regenerative alterations. The study revealed that chorpyrifos-induced changes in lipid and protein profile were improved by supplementation of certain herbs.

KEYWORDS:

Broilers; chlorpyrifos; lipid profile; protein profile

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