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Mucosal Immunol. 2011 May;4(3):252-60. doi: 10.1038/mi.2011.13. Epub 2011 Mar 23.

Role of innate cytokines in mycobacterial infection.

Author information

1
Trudeau Institute, Saranac Lake, New York, USA. acooper@trudeauinstitute.org

Abstract

Cells of the innate immune system produce cytokines and lipid mediators that strongly influence the outcome of mycobacterial infection. In the case of Mycobacterium tuberculosis, the lung is a critical site for this interaction. Here, we review current information on the role of the major innate cytokine pathways both in controlling initial infection as well as in promoting and maintaining adaptive T-cell responses that mediate host resistance or immunopathology. Understanding this important feature of the host-pathogen interaction can provide major insights into the mechanisms of virulence and can lead to new approaches for immunological intervention in tuberculosis and other mycobacterial diseases.

PMID:
21430655
PMCID:
PMC3294290
DOI:
10.1038/mi.2011.13
[Indexed for MEDLINE]
Free PMC Article

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